Abstract: To address safety management issues in rural power grids with high penetration of renewable energy, this paper takes a regional case study to analyze the current status and challenges of rural renewable energy grid integration, including impacts on power flow and voltage. Weaknesses in voltage and reactive power during the grid connection and consumption process are identified. Based on relevant national policies, the paper proposes specific safety management measures for regional power grids under high renewable penetration, including establishing management systems, conducting training, performing inspections and rectifications, and dynamically tracking issues. Typical renewable energy plants and associated substations are selected to implement the proposed measures. The operational performance and outcomes are analyzed to verify the necessity and feasibility of safety management for rural renewable energy grid connection.